Skip to main content
. 2017 Dec 10;8(6):437–446. doi: 10.5306/wjco.v8.i6.437

Table 1.

Comparing maximum tolerated dose chemotherapy vs metronomic chemotherapy

Maximum tolerated dose chemotherapy (conventional) Metronomic chemotherapy
Dose High doses Low doses or biologic optimal doses
Administration Administered at defined intervals (3 weekly, weekly) determined by the recovery of bone marrow Dosing frequency is continuous (weekly, every other day, daily)
Plasma concentration Rise and fall of the plasma concentration of the drug Sustained plasma concentration of the drug
Target Proliferating tumor cells Endothelial cells in the growing vasculature of the tumor
Toxicity Acute and cumulative toxicity is a concern Acute toxicity is rare. Cumulative toxicity is unknown, except for etoposide (related to leukemia)