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. 2017 Dec 21;7:18015. doi: 10.1038/s41598-017-18237-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Confocal maximum projections of the dentate hilus showing immunostaining for microglial (Iba1, red) and astrocytic (GFAP, green) markers. (a) Healthy-control that received diphtheria toxin but lacked the receptor, so ablation did not occur (C + DT, −A). (b) Healthy-control that expressed the diphtheria toxin receptor, but received saline, so ablation did not occur (C + NaCl, −A). (c) Healthy-ablation, expressing the receptor and receiving toxin (C + DT, + A). (d) SE-control that received toxin but lacked the receptor (SE + DT, −A). (e) SE-control that expressed the diphtheria toxin receptor, but received saline (SE + NaCl, −A). (f) SE-ablation, expressing the receptor and receiving toxin (SE + DT, + A). Scale bar = 50 µm. (g) Graph showing the average soma area for GFAP immunopositive astrocytes. Status epilepticus was associated with increased astrocyte soma area. ***p < 0.001 vs. Group B. *p < 0.05 vs. Group B. ^##p < 0.01 vs. Group A. (h) Graph detailing the average soma area for Iba1 positive microglia cells within each treatment group. Status epilepticus (SE) was associated with increased microglial soma area. **p < 0.01 vs. Group B. *p < 0.05 vs. Group B. ^#p < 0.05 vs Group C. See Table 1 for group details.