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. 2017 Dec 21;7:17978. doi: 10.1038/s41598-017-18210-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AR overexpression sensitizes AURKA under androgen regulation. LNCaP-cells were stably transfected to overexpress 8- to 10-fold higher wt-AR (LNCaP-ARhi) compared to that in empty vector LNCaP-pcDNA3.1 cells. Bar plots show the relative expression quantified with qRT-PCR and normalized to TBP. Relative KLK3 expression in (a) LNCaP-pcDNA3.1 and (b) LNCaP-ARhi cells and relative AURKA expression in (c) LNCaP-pcDNA3.1 and (d) LNCaP-ARhi after 8 and 12 h of treatment with DHT (10 ng) with and without CHX (10 µg). *P < 0.05 and **P < 0.01, unpaired t test.