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. 2017 Dec 21;7:17978. doi: 10.1038/s41598-017-18210-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activity of ARBS in promoter and intronic regions of AURKA. A luciferase assay was performed in LNCaP-ARhi cells with different DHT concentrations (0, 10 or 100 nM). Cells were transfected with pGL3-basic-LUC (LUC), pGL3-PSA5.8-LUC (PSA), pGL3-AURKApromoter-LUC (AURKA) and pGL3-AURKAenhancer-LUC (AURKA enh.), and luciferase activities were normalized to the renilla control plasmid (LUC). (a) Activity of AR binding to the AURKA promoter and positive (PSA) as well as negative control regions with different androgen stimulation. (b) Activity of AR binding to the AURKA enhancer and promoter with enhancer region and positive (PSA) and negative control (pGL3) regions with different androgen stimulation. *P < 0.05; n.s. = not significant. The means ± s.d. are shown.