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. 2017 Dec 21;7:17978. doi: 10.1038/s41598-017-18210-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AURKA expression and correlation in clinical prostate cancer specimens. (a) AURKA expression (qRT-PCR) in an independent prostate cancer cohort of 8 BPH, 27 hormone-naïve prostatectomy prostate cancer patients and 16 CRPC specimens. *P = 0.038 and **P = 0.002, unpaired t test. (b) AURKA correlation with AR in 39 AR-positive prostate cancer specimens¹⁹. r(Pearson) = 0.751, p < 0.0001. (c) Representative AURKA IHC stains showing negative (upper panel) and positive stains with > 1% (middle) and ~80% (bottom) of prostate cancer cells. (d) Proportions of AURKA positive samples in hormone untreated prostate cancer, local CRPC, met-CRPC specimens and CRPC patients. (e) Kaplan-Meier analysis of biochemical recurrence (BCR) in hormone naïve prostate cancer patients. AURKA positive (with > 1% of the tumor cells, red line) patients had a significantly worse BCR rate. P-value = 0.017, Mantel-Cox test.