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. 2017 Dec 21;7:17978. doi: 10.1038/s41598-017-18210-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relative growth of LNCaP-AR cells treated with the AURKA-specific inhibitor, alisertib. The relative growth of (a) LNCaP-pcDNA3.1, (b) LNCaP-ARmo, and (c) LNCaP-ARhi cells. All cells were equally seeded on 12-well plates and treated with vehicle (DMSO) or with 10 and 100 nM alisertib (MLN8237) in triplicate. The area of the attached cells in each well was measured daily and divided by the mean from day 1. (d) The relative cell viability of LNCaP-pcDNA3.1, LNCaP-ARmo, and LNCaP-ARhi cells at day 4 measured by Alamar blue and normalized to day 1 of each cell line. NT = no treatment. *p < 0.05, **p < 0.01, and ***p < 0.001, unpaired t test.