Table 2.
Association of AR, EZH2, Ki67, PTEN and SPINK with AURKA in CRPC specimens. AURKA positivity was associated with staining of AR, Ki67, EZH2 and PTEN expression levels in AR positive CRPC samples (NEPCs were excluded from the analysis)
| Variable | AURKA expression | P | |
|---|---|---|---|
| Negative | Positive | ||
| Met-CRPCs: | |||
| AR expression, n (%)a | |||
| weak | 31 (44) | 4 (20) | |
| moderate | 30 (43) | 7 (35) | |
| strong | 9 (13) | 9 (45) | 0.005 |
| ERG expression, n (%)b | |||
| negative | 37 (60) | 4 (20) | |
| positive | 25 (40) | 16 (80) | 0.004 |
| PTEN expression, n (%)b | |||
| negative | 42 (68) | 11 (55) | |
| positive | 20 (32) | 9 (45) | 0.420 |
| p53 expression, n (%)b | |||
| negative | 40 (62) | 16 (84) | |
| positive | 25 (38) | 3 (16) | 0.096 |
| SPINK expression, n (%)b | |||
| negative | 54 (87) | 16 (80) | |
| positive | 8 (13) | 4 (20) | 0.474 |
| Ki-67 (mean +/− SD)d | 9.3 (9.5) | 14.5 (9.3) | 0.025 |
| EZH2 (mean +/− SD)d | 27.9 (22.4) | 39.6 (20.4) | 0.035 |
| Local CRPCs | |||
| AR expression, n (%)a | |||
| weak | 1 (4) | 1 (6) | |
| moderate | 9 (39) | 6 (38) | |
| strong | 13 (57) | 9 (56) | 0.073 |
| ERG expression, n (%)b | |||
| negative | 10 (38) | 9 (56) | |
| positive | 16 (62) | 7 (44) | 0.344 |
| PTEN expression, n (%)b | |||
| negative | 6 (60) | 7 (58) | |
| positive | 4 (40) | 5 (42) | 1.000 |
| SPINK expression, n (%)b | |||
| negative | 12 (86) | 8 (67) | |
| positive | 2 (14) | 4 (33) | 0.365 |
| Ki-67 (mean +/− SD)d | 14.4 (9.1) | 18.1 (11.1) | 0.318 |
| EZH2 (mean +/− SD)d | 39.2 (29.6) | 58.9 (21.9) | 0.032 |
aχ2 test.
bFisher’s exact test.
cUnpaired t test.