Figure 1.

LU‐005i reduces H‐2K^b surface expression on splenocytes. (A) Structure of LU‐005i (left side) or LU‐001i (right side). (B, C) Flow cytometry analysis of H‐2K^b surface expression on splenocytes derived from C57BL/6 (left side) or LMP7^−/− (right side) mice treated with the indicated concentrations of LU‐005i (B) or LU‐001i (C) overnight. Pooled data from five independent experiments performed in triplicates are shown as the means of median fluorescent intensity ± SEM. All data were statistically compared to the DMSO treated group. *P < 0.05.