Figure 2.

LU‐005i blocks MHC‐I–restricted presentation of an LMP7‐dependent epitope. Presentation of UTY_246–254 on MHC‐I by wild‐type (WT) splenocytes after exposure to the indicated concentrations of LU‐005i (A) or LU‐001i (B), as analysed by exposure to H‐2D^b‐UTY_246–254‐specific, LacZ‐expressing T cell hybridomas. Female, LMP7‐deficient and ONX 0914 (300 nM) treated splenocytes were used as controls. Pooled data from five independent experiments conducted in triplicates are shown as means ± SEM. All data were statistically compared to the WT male group. *P < 0.05.