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. 2017 Oct 30;4(12):865–876. doi: 10.1002/acn3.492

Figure 8.

Figure 8

Pre‐ and Post‐SAH minocycline treatment attenuates vasospasm in rabbits. Rabbits were subjected to sham surgery or cisterna magna double‐hemorrhage SAH. The rabbits undergoing SAH were administered vehicle (Veh), minocycline 2 h prior to SAH (Mino‐Pre), and 1 h after SAH (Mino‐Post). Vasospasm was assessed by measurement of basilar artery cross‐sectional area and wall thickness 5 days after the second hemorrhage. (A) Representative cross‐sectional images of basilar artery. (B) Basilar artery area measurements. Data represent mean±SEM. *P < 0.05 vs. Sham, and # P < 0.05 vs. SAH:Veh by one‐way ANOVA with Tukey's multiple comparisons test. (B) Basilar artery wall thickness measurements. Data represent mean ± SEM. *P < 0.05 vs. Sham, and #P < 0.05 vs. SAH:Veh by one‐way ANOVA with Tukey's multiple comparisons test.