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. 2017 Dec 8;175(1):125–139. doi: 10.1111/bph.14078

Figure 7.

Figure 7

Effect of LY294002 and PD98059 on the activation of Akt and ERK1/2 and the survival effects of IGF‐1 on amiodarone‐treated D407 cells. D407 cells pretreated with LY294002 to block PI3K/Akt signalling or PD98059 to block the MAPK (ERK1/2) pathway were treated with IGF‐1 and then incubated with (AM) or without (CTL) amiodarone as indicated. Cell viability (A) and caspase 3/7 activity (B) were determined. Data are presented as means ± SEM of the results obtained from five to six experiments. #P < 0.05 versus control, *P < 0.05 versus amiodarone‐treated group.