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. 2017 Dec 8;175(1):125–139. doi: 10.1111/bph.14078

Figure 8.

Figure 8

Effect of LY294002 on the activation of Akt and the IGF‐1 mediated attenuation of the damaging effects of amiodarone (AM) on D407 cells injury. D407 cells, pretreated with LY294002 to block PI3K/Akt signalling or PD98059 to block the MAPK (ERK1/2) pathway, were treated with IGF‐1 and then incubated with (AM) or without (CTL) amiodarone as indicated. Data are presented as means ± SEM of the results obtained from five experiments. #P < 0.05 versus control, *P < 0.05 versus amiodarone‐treated group.