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Schematic presentation of the antioxidant and protective effects of IGF‐1 on amiodarone‐treated human retinal pigment epithelial cells. Amiodarone inhibited the activation of Akt, increased ROS/MDA and induced mitochondrial membrane failure and the activation of caspase, causing the apoptosis of D407 cells while IGF‐1 reversed the effects of amiodarone and promoted the survival of D407 cells.
