Table 2.

Metabolic parameters, kidney weight and renal function

	Ctrl	Ctrl‐FL‐926‐16	Diab	Diab‐FL‐926‐16
Body weight, g	34.5 ± 3.0	33.8 ± 1.7	45.5 ± 2.0*	45.6 ± 7.6*
Glucose, mmol·L−1	9.18 ± 0.43	9.11 ± 0.63	29.74 ± 2.43*	28.95 ± 2.38*
Insulin, pmol·L−1	72.6 ± 8.1	73.0 ± 10.5	254.4 ± 18.8*	251.3 ± 15.6*
HOMA‐IR	4.27 ± 0.51	4.23 ± 0.49	48.20 ± 1.81*	46.39 ± 1.91*
Cholesterol, mmol·L−1	1.98 ± 0.24	1.98 ± 0.15	3.80 ± 0.41*	3.81 ± 0.40*
Triglycerides, mmol·L−1	0.76 ± 0.10	0.77 ± 0.07	1.09 ± 0.10*	1.06 ± 0.10*
8‐epi‐PGF2α, pg·mL−1	71.0 ± 4.7	70.4 ± 2.4	165.6 ± 8.8*	77.6 ± 13.3†
PCOs, pmol·mg·prot−1	1.57 ± 0.06	1.56 ± 0.13	3.12 ± 0.34*	1.94 ± 0.16†
AGEs, U·mL−1	5.37 ± 0.64	4.94 ± 0.83	10.57 ± 1.30*	6.67 ± 1.09†
Pentosidine, pg·mL−1	N/A	N/A	N/A	N/A
P‐FL‐926‐16, μmol·L−1	N/A	N/A	N/A	N/A
U‐FL‐926‐16, μmol·L1	N/A	N/A	N/A	N/A
Kidney weight, mg	234.0 ± 19.5	232.0 ± 14.8	278.0 ± 14.8*	256.0 ± 11.4
Creatinine, μmol·L−1	31.5 ± 1.3	31.3 ± 1.6	62.1 ± 6.4*	50.7 ± 5.9*, †
Urinary P/C, mg·g−1	2.03 ± 0.32	2.08 ± 0.09	44.65 ± 7.89*	28.04 ± 4.84*, †
Urinary A/C, mg·g−1	1.42 ± 0.23	1.43 ± 0.22	33.48 ± 4.96*	19.65 ± 2.63*, †

Values of untreated and FL‐926‐16‐treated db/m and db/db mice at 34 weeks of age (regression protocol; n = 5 per group).

Kidney weight refers to both kidneys. HOMA‐IR, Homeostasis Model of Assessment – Insulin Resistance; N/A, not assessed; Post hoc multiple comparison:

^* P < 0.05 versus Ctrl;

^† P < 0.05 versus Diab.