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. 2017 Dec 8;175(1):154–161. doi: 10.1111/bph.14082

Figure 1.

Figure 1

Lodoxamide induced the activation of GPR35, and this activation was inhibited by CID2745687 (a GPR35 selective antagonist). (A) Concentration–response curves for lodoxamide, pamoic acid and zaprinast as determined by the AP‐TGFα shedding assay. Agonism of GPR35 agonists was examined in GPR35 coexpressed with a mixture of eight Gα proteins in HEK‐293 cells. Results are presented as the means ± SEM of three individual experiments. (B) Inhibition of the lodoxamide‐induced GPR35 activation by CID2745687. Antagonism by CID2745687 was tested in the presence of 10 nM of lodoxamide. Results are presented as the means ± SEM of three individual experiments.