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GPR35 coupling of G proteins. AP‐TGFα release responses were measured in human GPR35‐transfected HEK‐293 cells, in which eight Gα proteins were coexpressed individually. In Gαq/i1, Gαq/i3, Gαq/o, Gαq/12 or Gαq/13‐coexpressing cells, GPR35 induced potent AP‐TGFα shedding responses, whereas Gαq/s, Gαq/z or Gα16‐coexpressing cells did not. Results are presented as the means ± SEM of three individual experiments.
