TABLE 3.
Gyrase mutations and MICs for 53 M. tuberculosis clinical strains
| Mutation | No. of strains | No. of resistant strainsa |
MIC (μg/ml) |
||
|---|---|---|---|---|---|
| MOFX | GTFX | STFX (mode) | OFX (mode) | ||
| GyrA | |||||
| Asp94Gly | 22 | 12 | 4 | 0.125–0.5 (0.25) | 2–8 (8) |
| Asp94Ala | 6 | 0 | 0 | 0.0625–0.25 (0.0625) | 2–8 (2) |
| Asp94Asn | 4 | 3 | 0 | 0.25–0.5 (0.5) | 8–16 (8) |
| Asp94His | 3 | 3 | 0 | 0.25–0.5 (0.25) | 4–8 (4) |
| Asp94Tyr | 2 | 1 | 0 | 0.0625–0.125 | 4–8 |
| Ala90Val | 8 | 4 | 2 | 0.125–0.5 (0.125) | 2–16 (2) |
| Ala90Val Asp94Ala | 2 | 2 | 1 | 0.5–1 | 16 |
| Ala90Val Asp94Asn | 1 | 1 | 0 | 0.625 | 4 |
| GyrB | |||||
| Glu540Asp | 4 | 4 | 0 | 0.031–0.125 (0.0625) | 0.5–1 (0.5) |
| Asn538Asp Asp656Tyr | 1 | 0 | 1 | 0.25 | 4 |
a
Critical concentration, 2 μg/ml.