TABLE 1.
Interactions of isavuconazole with echinocandins against Aspergillus spp., determined with the checkerboard broth microdilution techniquea
| Species | FICI (mean [range])b |
|||||
|---|---|---|---|---|---|---|
| Isavuconazole with caspofunginc |
Isavuconazole with micafunginc |
Isavuconazole with anidulafunginc |
||||
| MIC | MEC | MIC | MEC | MIC | MEC | |
| Azole-resistant A. fumigatus (5 isolates) | 1.025 (1–1.125) | 0.928 (0.5–2) | 1.201 (1.001–2.001) | 0.71 (0.312–1.5) | 1.201 (1.001–2.001) | 0.732 (0.531–1.25) |
| Azole-susceptible A. fumigatus (5 isolates) | 1.201 (1.001–2.001) | 0.577 (0.31–1) | 1.001 | 0.37 (0.317–0.517) | 1.401 (1.001–2.001) | 0.643 (0.5–1.033) |
| A. niger (5 isolates) | 1.126 (0.625–2.001) | 0.409 (0.059–1.062) | 1.001 | 0.621 (0.164–2.033) | 1.104 (0.516–1.001) | 0.663 (0.158–2.033) |
| A. terreus (5 isolates) | 1.001 | 0.875 (0.37–1.007) | 1.001 | 0.907 (0.375–1.062) | 1.001 | 0.873 (0.5–1.033) |
| A. flavus (5 isolates) | 0.926 (0.625–1.001) | 0.832 (0.528–1.014) | 1.201 (1.001–2.001) | 0.633 (0.317–1.017) | 1.101 (0.501–2.001) | 0.662 (0.508–1.017) |
| A. nidulans (5 isolates) | 1.001 | 1.034 (1.028–1.056) | 1.001 | 0.937 (0.562–1.033) | 1.001 | 1.031 (1.008–1.062) |
a
The effects of isavuconazole in combination with echinocandins against 30 Aspergillus isolates were determined with the checkerboard broth microdilution technique, using two different endpoints.
b
Corresponding to the lowest FICI values.
c
MIC corresponds to complete inhibition of growth for both drugs, and MEC corresponds to the lowest drug concentrations resulting in aberrant hyphal growth for both drugs.