TABLE 3.
Interactions of isavuconazole with echinocandins against Aspergillus spp., determined with gradient concentration stripsa
| Species (no. of isolates) | Isavuconazole with caspofungin |
Isavuconazole with micafungin |
Isavuconazole with anidulafungin |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FICI range | No. of isolates |
FICI range | No. of isolates |
FICI range | No. of isolates |
|||||||
| S | I | A | S | I | A | S | I | A | ||||
| Azole-resistant A. fumigatus (5) | 1.011–3.294 | 0 | 5 | 0 | 1.001–1.024 | 0 | 5 | 0 | 0.688–1.016 | 0 | 5 | 0 |
| Azole-susceptible A. fumigatus (5) | 0.425–2.291 | 1 | 4 | 0 | 1.008–1.024 | 0 | 5 | 0 | 0.774–1.024 | 0 | 5 | 0 |
| A. niger (5) | 1.016–5.601 | 0 | 3 | 2 | 1.002–1.341 | 0 | 5 | 0 | 1.001–1.502 | 0 | 5 | 0 |
| A. terreus (5) | 0.084–1.046 | 3 | 2 | 0 | 1.005–1.008 | 0 | 5 | 0 | 1.005–1.010 | 0 | 5 | 0 |
| A. flavus (5) | 1.042–2.084 | 0 | 5 | 0 | 1.005–1.349 | 0 | 5 | 0 | 0.508–1.024 | 0 | 5 | 0 |
| A. nidulans (5) | 0.630–3.061 | 0 | 5 | 0 | 0.917–1.170 | 0 | 5 | 0 | 1.004–1.042 | 0 | 5 | 0 |
| Total (30) | 0.084–5.601 | 4 | 24 | 2 | 0.917–1.349 | 0 | 30 | 0 | 0.508–1.502 | 0 | 30 | 0 |
a
Interactions between the antifungal agents were analyzed using FICI values. MICs were determined with partial inhibition endpoints. S, synergism; I, indifference; A, antagonism.