TABLE 2.

MICs of fosfomycin with G6P (25 μg/ml) against isogenic E. coli strains in MH broth and urine at different pH values^a

Strain	FOS MIC (μg/ml)
	MH broth at pH 7.4		Urine at pH 7		Urine at pH 6		Urine at pH 5
	O2	nO2	O2	nO2	O2	nO2	O2	nO2
ATCC 25922	2	1	4	2	1	1	2	1
BW25113	2	1	4	2	2	1	2	2
ΔcyaA	16	16	32	16	32	16	32	16
ΔglpT	2	1	16	2	8	4	1	1
ΔuhpT	64	16	64	16	32	8	16	2
ΔptsI	4	2	64	32	32	32	32	32
ΔglpT ΔuhpT	256	64	128	64	64	32	8	8
ΔglpT ΔptsI	128	64	32	8	16	8	16	4
ΔcyaA ΔglpT	128	32	64	64	64	64	64	64
ΔptsI ΔcyaA	128	32	128	64	64	32	32	32
ΔuhpT ΔcyaA	512	128	256	128	128	128	128	64
ΔptsI ΔuhpT	128	8	256	32	256	32	64	8

^aMIC values indicating resistance (according to EUCAST guidelines) are shown in bold. O₂, aerobic conditions; nO₂, anaerobic conditions.