TABLE 2.
PK parameters for DTG and MDTG
| PK parametera | DTGb |
MDTG |
||
|---|---|---|---|---|
| Avg | SEM | Avg | SEM | |
| λZ (h−1) | 0.0015 | 0.0001 | 0.0016 | 0.0002 |
| t1/2 (h) | 467.1 | 28.1 | 458.2 | 55.7 |
| AUClast (h · ng/ml) | 235,061.6 | 33,152.3 | 40,864.0 | 16,260.0 |
| AUC0–∞ (h · ng/ml) | 249,640.2 | 35,707.7 | 41,937.7 | 16,271.1 |
| Vβ/F (liters/kg) | ND | — | 835.5 | 334.0 |
| CL/F (liters/h/kg) | ND | — | 1.19 | 0.36 |
| MRT0–∞ (h) | 691.7 | 98.4 | 454.6 | 62.5 |
a
In the units of measure for the area under the concentration-time curve (AUC) data, 1 ml is equivalent to 100 × 106 cells. λZ, individual estimate of the terminal elimination rate constant; AUClast, AUC 0 h to last time point; AUC0–∞, AUC from 0 h to infinity; Vβ, volume of distribution at β phase; CL, clearance; MRT, mean residence time. PK parameters are calculated from the mean of the results from 3 monkeys.
b
SEM, standard error of the mean; ND, not determined.