TABLE 3.
Cumulative MIC distributions for meropenem-vaborbactam stratified by KPC variant
| KPC variant (no. of isolates) | No. of isolates (cumulative % of isolates) inhibited at MIC (μg/ml)a of: |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | |
| KPC-2 (610) | 294 (48.2) | 42 (55.1) | 39 (61.4) | 67 (72.5) | 79 (85.4) | 46 (93.0) | 27 (97.4) | 11 (99.2) | 4 (99.8) | 0 (99.8) | 0 (99.8) | 1 (100) |
| KPC-3 (373) | 161 (43.2) | 13 (46.6) | 18 (51.5) | 68 (69.7) | 58 (85.3) | 34 (94.4) | 12 (97.6) | 4 (98.7) | 2 (99.2) | 2 (99.7) | 0 (99.7) | 1 (100) |
| KPC-5 (2) | 1 (50.0) | 0 (50.0) | 1 (100) | |||||||||
| KPC-6 (1) | 1 (100) | |||||||||||
| KPC-9 (2) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2 (100) | |||||||
| KPC-18 (3) | 3 (100) | |||||||||||
| All isolates (991) | 460 (46.4) | 55 (52.0) | 58 (57.8) | 135 (71.4) | 139 (85.5) | 80 (93.5) | 39 (97.5) | 15 (99.0) | 6 (99.6) | 2 (99.8) | 0 (99.8) | 2 (100) |
a
MIC90s are in boldface when 10 or more isolates of a KPC variant were present.