TABLE 2.
TMP PopPK parameter estimates from the final modela
| Parameter | Final model |
Bootstrap analysis (n = 1,000)b |
|||
|---|---|---|---|---|---|
| Estimate | RSE (%) | 2.5th percentile | Median | 97.5th percentile | |
| Ka (h−1) | 1.27 | 35.8 | 0.6 | 1.27 | 2.4 |
| CL/F70 kg (liters/h) | 10.0 | 5.5 | 8.8 | 9.9 | 11.0 |
| V/F70 kg (liters) | 148 | 6.8 | 129 | 148 | 173 |
| TM50 (yr) | 0.24 | 24.8 | 0.14 | 0.24 | 0.40 |
| Hill | 1 (fixed) | ||||
| Exponent for SCR effect on CL/F | 0.40 | 20.4 | 0.26 | 0.41 | 0.57 |
| IIV(CL/F) (% CV) | 33.8 | 36.8 | 10.0 | 31.6 | 44.7 |
| IIV(V/F) (% CV) | 20.6 | 89.2 | 4.7 | 22.3 | 50.1 |
| Proportional error (%) | 51.1 | 14.4 | 42.3 | 50.0 | 57.6 |
TMP, trimethoprim; PK, pharmacokinetic; RSE, relative standard error; Ka, population absorption rate constant; CL/F70 kg, apparent population clearance estimate scaled to a 70-kg adult; V/F70 kg, apparent population volume of distribution estimate scaled to a 70-kg adult; TM50, maturation half-life calculated as a function of postnatal age (in years); Hill, Hill coefficient in the Emax maturation function; SCR, serum creatinine concentration; IIV(CL/F), interindividual variability in drug clearance; IIV(V/F), interindividual variability in the volume of distribution; CV, coefficient of variation.
Altogether, 39 runs with minimization terminated were skipped when the bootstrap results were calculated; 249 runs with estimates near a boundary were skipped when the bootstrap results were calculated.