TABLE 3.
TMP individual empirical Bayesian post hoc parameter estimates stratified by age
| PK parametera | Median (range) value for the following age groups (yr)b: |
|||
|---|---|---|---|---|
| 0 to <2 (n = 46) | 2 to <6 (n = 25) | 6 to <21 (n = 82) | Total (n = 153) | |
| CL/F (liters/h/kg) | 0.25 (0.05–0.44) | 0.23 (0.14–0.43) | 0.14 (0.04–0.31) | 0.16 (0.04–0.44) |
| CL/F (liters/h/70 kg) | 9.6 (1.5–18.1) | 11.4 (6.2–21.4) | 9.3 (2.5–18.0) | 9.6 (1.5–21.4) |
| V/F (liters/kg) | 2.1 (1.8–2.5) | 2.1 (1.8–2.4) | 2.1 (1.4–2.4) | 2.1 (1.4–2.5) |
| V/F (liters/70 kg) | 149 (125–175) | 149 (127–171) | 147 (96–168) | 148 (96.2–175) |
| Half-life (h) | 5.9 (3.3–33.2) | 6.5 (3.1–11.3) | 11.1 (4.3–32.6) | 8.7 (3.1–33.2) |
a
CL/F, clearance; V/F, volume of distribution.
b
Values were calculated using age at the time that the first pharmacokinetic sample was collected.