TABLE 5.
Simulated trimethoprim exposure at steady state
| Age group (yr) | No. of subjects | AUC0–τ,ss (mg · h/liter)a |
|||||
|---|---|---|---|---|---|---|---|
| Oral dosing every 12 h |
Oral dosing every 8 h |
Oral dosing every 6 h |
|||||
| 8 mg/kg/dayb | 12 mg/kg/dayc | 15 mg/kg/dayd | 20 mg/kg/daye | 15 mg/kg/dayf | 20 mg/kg/dayg | ||
| 0 to <2 | 500 | 19.2 (9.2, 59.1) | 28.7 (13.8, 88.7) | 23.9 (11.5, 73.9) | 32.1 (15.4, 99.0) | 17.9 (8.6, 55.4) | 23.9 (11.5, 73.9) |
| 2 to <6 | 500 | 19.0 (9.8, 35.9) | 28.5 (14.7, 53.8) | 23.8 (12.2, 44.9) | 31.8 (16.4, 60.1) | 17.8 (9.2, 33.6) | 23.8 (12.2, 44.9) |
| 6 to <21 | 1,500 | 22.8 (11.4, 45.7) | 36.2 (18.0, 76.5) | 30.7 (15.7, 63.7) | 41.0 (21.0, 85.4) | 23.1 (11.8, 47.8) | 30.7 (15.7, 63.7) |
| 18 to 21 (70 kg) | 500 | 19.5 (10.2, 39.5) | 39.1 (20.3, 79.0) | 42.8 (22.2, 86.4) | 57.3 (29.7, 115.7) | 32.1 (16.6, 64.8) | 42.8 (22.2, 86.4) |
Data are presented as the median (2.5th, 97.5th percentile). AUC0–τ,ss, steady-state area under the concentration-versus-time curve from time zero to τ (where τ denotes the dosing interval).
Maximum daily dose, 320 mg (1 double-strength tablet every 12 h) achieved at a WT of 40 kg.
Maximum daily dose, 640 mg (2 double-strength tablets every 12 h) achieved at a WT of 53 kg.
Maximum daily dose, 1,200 mg (2 double-strength tablets + 1 single-strength tablet every 8 h) achieved at a WT of 60 kg.
Maximum daily dose, 1,440 mg (3 double-strength tablets every 8 h) achieved at a WT of 72 kg.
Maximum daily dose, 1,280 mg (2 double-strength tablets every 6 h) achieved at a WT of 85 kg.
Maximum daily dose, 1,600 mg (2 double-strength tablets + 1 single-strength tablet every 6h) achieved at a WT of 80 kg.