TABLE 4.

Cox proportional hazards regression models for renal failure^a

Variable	Final model		Alternative model 1		Alternative model 2		Alternative model 3
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Treatment with another nephrotoxic drugb	2.50 (1.02–6.14)	0.046	2.50 (1.01–6.22)	0.048	2.31 (0.95–5.65)	0.065	2.47 (0.99–6.19)	0.053
Treatment with a vasoactive drug	2.75 (1.17–6.43)	0.020	2.75 (1.17–6.44)	0.020	2.82 (1.20–6.63)	0.018	1.78 (1.18–6.57)	0.019
Baseline creatinine clearance (ml/min)	1.01 (1.00–1.01)	0.035	1.01 (1.00–1.01)	0.035	1.01 (1.00–1.01)	0.030	1.01 (1.00–1.01)	0.034
PMB dose (mg/kg/day)	0. 78 (0.49–1.27)	0.324	0.78 (0.43–1.41)	0.422	—	—	—	—
Total daily dose (mg)	—	—	—	—	1.00 (0.99–1.01)	0.986	0.99 (0.99–1.01)	0.792
Wt (kg)	—	—	1.00 (0.98–1.02)	0.999	—	—	1.01 (0.98–1.03)	0.485

^aPMB, polymyxin B; HR, hazard ratio; CI, confidence interval; —, not included or not performed.

^bVancomycin, aminoglycosides, and amphotericin B.