FIG 1.

Pharmacokinetic profiles of bedaquiline and clofazimine, with or without verapamil, in mice. (A to C) Median plasma concentration-time profiles for 12.5 mg/kg bedaquiline [B(12.5)] (A), 25 mg/kg bedaquiline [B(25)] (B), and 12.5 mg/kg clofazimine [C(12.5)] (C) after administration alone or with verapamil (V). The insets in panels A and B depict the first 24 h only, to allow clearer inspection of the curves at the early time points for bedaquiline. (D) Pharmacokinetic parameters calculated from the profiles, using the median concentration at each time point.