FIG 1.

Representative histological images of hematoxylin-eosin-stained kidney sections from mice in the control and treatment groups. (A) Kidney sections from saline-treated control mice showing normal glomeruli and renal tubules; (B) kidney sections from mice treated with polymyxin B showing severely damaged and dilated tubules (arrow 1), degeneration and necrosis of tubular epithelial cells, and tubular casts (arrow 2); (C) kidney sections from mice treated with polymyxin B plus methionine at 100 mg/kg showing damaged tubules with mild tubular dilation (arrow 1) and degeneration and tubular casts (arrow 2); (D) kidney sections from mice treated with polymyxin B plus methionine at 400 mg/kg showing normal glomeruli and renal tubules without significant lesions.