TABLE 1.
Histological results for kidneys collected from mice in each groupa
| Treatment | Overall kidney damage score | SQS for kidney damageb |
|---|---|---|
| Polymyxin B | 5, 4, 0, 24, 0, 3 | +1, +2, 0, +2, 0, +1 |
| Polymyxin B + methionine 100 | 0, 0, 3, 2, 2, 0 | 0, 0, +1, +1, +1, 0 |
| Polymyxin B + methionine 400 | 0, 0, 0, 0, 0, 0 | 0, 0, 0, 0, 0, 0 |
a
In the groups treated with the saline control and methionine alone, no kidney damage was observed, and therefore, data for these groups are not included here.
b
The extent of kidney lesions was graded using the SQS, where 0, +1, and +2 correspond to no change, mild damage, and mild to moderate damage, respectively (16).