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TBZ exposure changes in the expression of efflux pumps and ERG11 genes. Expression of PDR1 (A) and MDR1 (B), but not that of ERG11 (C), was altered by tebuconazole exposure in C. gattii R265. In C. neoformans H99, the levels of expression of AFR1 (D), MDR1 (E), and ERG11 (F) were increased in adapted cells versus nonadapted cells. NA, nonadapted; A, TBZ adapted; *, P < 0.05; **, P < 0.01.
