TABLE 1.
Demographic and baseline characteristicsa
| Patient variable | Value for: |
|||||
|---|---|---|---|---|---|---|
| Primary population |
PSM population |
|||||
| CST (n = 4,817) | CST-MIN (n = 93) | P valueb | CST (n = 664) | CST-MIN (n = 83) | Absolute standard difference (%) | |
| Age (yr) | ||||||
| Mean ± SD | 61.3 ± 16.0 | 64.6 ± 16.2 | 0.040 | 63.6 ± 14.6 | 63.4 ± 16.0 | 1.7 |
| Median (Q1, Q3) | 63 (52, 73) | 66 (57, 77) | 65 (55, 75) | 65 (56, 74) | ||
| Age ≥ 65 yr, % | 45.9 | 53.8 | 0.130 | 51.7 | 50.6 | 2.1 |
| Male, % | 58.2 | 48.4 | 0.058 | 51.4 | 50.6 | 1.5 |
| White, % | 58.4 | 62.4 | 0.735 | 63.3 | 62.7 | 1.2 |
| Primary payer, % | ||||||
| Medicare | 61.3 | 63.4 | 0.598 | 63.3 | 61.4 | 3.7 |
| Medicaid | 19.3 | 16.1 | 17.2 | 16.9 | 0.8 | |
| Commercial/managed | 14.1 | 17.2 | 14.8 | 18.1 | 9.0 | |
| Other | 5.2 | 3.2 | 4.8 | 3.6 | 6.0 | |
| CCI score | ||||||
| Mean ± SD | 3.1 ± 2.3 | 3.2 ± 2.3 | 0.519 | 3.2 ± 2.1 | 3.2 ± 2.3 | 2.9 |
| Median (Q1, Q3) | 3 (1, 4) | 3 (2, 4) | 3 (2, 4) | 3 (2, 4) | ||
| Charlson comorbidity, % | ||||||
| Myocardial infarction | 8.9 | 5.4 | 0.231 | 6.2 | 6.0 | 0.6 |
| CHF | 31.9 | 36.6 | 0.341 | 33.6 | 34.9 | 2.9 |
| PVD | 11.2 | 9.7 | 0.638 | 9.2 | 9.6 | 1.5 |
| Cerebrovascular disease | 10.9 | 6.5 | 0.168 | 9.8 | 7.2 | 9.2 |
| Dementia | 3.6 | 3.2 | 1.000 | 4.2 | 3.6 | 3.1 |
| COPD | 37.9 | 35.5 | 0.639 | 36.4 | 36.1 | 0.6 |
| Rheumatic disease | 3.2 | 4.3 | 0.567 | 3.6 | 4.8 | 6.0 |
| Peptic ulcer disease | 2.9 | 2.2 | 1.000 | 2.1 | 1.2 | 7.1 |
| Mild liver disease | 8.2 | 3.2 | 0.085 | 4.7 | 3.6 | 5.3 |
| Diabetes without complication | 36.4 | 33.3 | 0.549 | 36.6 | 34.9 | 3.5 |
| Diabetes with complication | 7.0 | 3.2 | 0.213 | 3.2 | 3.6 | 2.5 |
| Paraplegia and hemiplegia | 14.9 | 14.0 | 0.795 | 15.8 | 15.7 | 0.4 |
| Chronic renal disease | 37.1 | 50.5 | 0.008 | 47.0 | 47.0 | 0.0 |
| Cancer | 7.1 | 7.5 | 0.868 | 7.7 | 8.4 | 2.8 |
| Moderate/severe liver disease | 1.9 | 2.2 | 0.699 | 2.3 | 1.2 | 8.1 |
| Metastatic carcinoma | 2.6 | 1.1 | 0.733 | 1.8 | 1.2 | 4.9 |
| HIV/AIDS | 0.6 | 3.2 | 0.026 | 1.1 | 3.2 | 8.5 |
| Region, % | ||||||
| Midwest | 19.1 | 8.6 | <0.001 | 9.6 | 9.6 | 0.0 |
| Northeast | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| South | 55.1 | 90.3 | 89.2 | 89.2 | 0.0 | |
| West | 9.8 | 1.1 | 1.2 | 1.2 | 0.0 | |
| Urban hospital, % | 95.1 | 100.0 | 0.023 | 100.0 | 100.0 | 0.0 |
| Teaching hospital, % | 52.6 | 38.7 | 0.008 | 44.3 | 39.8 | 9.2 |
| Hospital bed size, % | ||||||
| 0–299 | 26.5 | 33.3 | 0.298 | 27.5 | 30.1 | 6.0 |
| 300–499 | 40.4 | 34.4 | 36.3 | 37.3 | 2.2 | |
| >500 | 33.0 | 32.3 | 36.3 | 32.5 | 7.9 | |
| Infection type, % | ||||||
| Pneumonia | 74.3 | 68.8 | 0.228 | 70.5 | 71.1 | 1.3 |
| Sepsis | 85.6 | 88.2 | 0.479 | 88.3 | 86.7 | 4.6 |
a
Abbreviations: PSM, propensity score matching; CST, colistin; CST-MIN, colistin-minocycline; CCI, Charlson comorbidity index; CHF, congestive heart failure; PVD, peripheral vascular disease; COPD, chronic obstructive pulmonary disease.
b
P values in bold indicate a significance difference.