TABLE 3.

Efficacy of meropenem alone and in combination with vaborbactam against K. pneumoniae UNT171-1 in a murine pyelonephritis model^a

Test	Dose (mg/kg) or day	n	Kidney log10 CFU		Change in log10 CFU vs:		P
			Mean	SD	Day 4	Meropenem alone
Meropenem	100	7	3.88	1.55	0.15	NA	0.431 vs untreated day 4; 0.026 vs 300 + 50 mg/kg
	300	6	2.35	0	−1.38	NA	0.021 vs untreated day 4; 0.079 vs 300 + 50 mg/kg
Meropenem + vaborbactam	300 + 50	6	2.48	0.21	−1.25	0.13	0.0317 vs untreated day 4
	100 + 50	7	2.40	0.11	−1.33	−1.48	0.024 vs untreated day 4; 0.218 vs 300 + 50 mg/kg; 0.027 vs 100 mg/kg
	100 + 25	7	2.46	0.2	−1.27	−1.42	0.041 vs untreated day 4; 0.436 vs 300 + 50 mg/kg; 0.017 vs 100 mg/kg
Untreated controls	Day 4	5	3.73	1.44	NA	NA	NA
	Day 5	7	4.05	0.66	0.32	NA	0.280 vs untreated day 4

^aNA, not applicable.