TABLE 4.

Efficacy of meropenem alone and in combination with vaborbactam against E. coli UNT167-1 in a murine pyelonephritis model^a

Test	Dose (mg/kg) or day	n	Kidney log10 CFU		Change in log10 CFU vs:		P
			Mean	SD	Day 4	Meropenem alone
Meropenem	100	7	5.78	1.23	−0.84	NA	0.119 vs untreated day 4; 0.003 vs 300 + 50 mg/kg
	300	6	5.8	1.29	−0.82	NA	0.138 vs untreated day 4; 0.004 vs 300 + 50 mg/kg
Meropenem + vaborbactam	300 + 50	6	3.82	0.31	−2.8	−1.98	0.0003 vs untreated day 4
	100 + 50	7	4.11	0.64	−2.51	−1.67	0.0003 vs untreated day 4; 0.197 vs 300 + 50 mg/kg; 0.006 vs 100 mg/kg
	100 + 25	7	4.41	1.38	−2.21	−1.37	0.006 vs untreated day 4; 0.378 vs 300 + 50 mg/kg; 0.07 vs 100 mg/kg
Untreated controls	Day 4	5	6.62	0.98	NA	NA	NA
	Day 5	7	7.09	0.21	0.47	NA	0.162 vs untreated day 4

^aNA, not applicable.