FIG 4.
PAB-CFZ combination causes enhanced killing of M. tuberculosis under replicating conditions. Kill kinetics under replicating conditions of IDR-0341930 at 10× the MIC in combination with CFZ at either 10× the MIC (A to C) or 1× the MIC. Combinations were tested against H37Rv-LP (A and D), H37Rv-MA (B and E), or H37Rv-MA cydC::aph (H37Rv-MA cydKO) (C and F). Samples were taken at the indicated times. Data are representative of at least two independent experiments. The dotted lines represent the upper and lower limits of detection (108 and 10 bacteria/ml, respectively).