TABLE 3.

Final Poisson regression models for vancomycin exposure thresholds and nephrotoxicity

Exposure threshold	Unadjusted		Adjusted
	RR (95% CI)	P value	RR (95% CI)	P value
AUC0–48 of ≥1,218 mg · h/liter	4.390 (1.500–12.845)	0.003	4.366a (1.559–12.226)	0.005
AUC0–24 of ≥677 mg · h/liter	3.405 (1.398–8.291)	0.004	3.734b (1.646–8.470)	0.002
AUC24–48 of ≥683 mg · h/liter	3.159 (1.332–7.491)	0.006	2.982a (1.293–6.878)	0.010
Cmin24 of ≥18.8 mg/liter	3.031 (1.179–7.791)	0.020	3.104c (1.243–7.755)	0.015

^aAdjusted for Elixhauser comorbidity index and concomitant intravenous contrast dye.

^bAdjusted for heart failure and APACHE II score.

^cAdjusted for renal disease and heart failure.