TABLE 4.
Final Cox proportional hazards regression models for time to nephrotoxicity
| Variable | Hazard ratio (95% CI) | P value |
|---|---|---|
| AUC0–48 of ≥1,218 mg · h/liter | 4.963 (1.634–15.072) | 0.005 |
| Concomitant i.v. contrast dye | 4.141 (1.696–10.109) | 0.002 |
| Elixhauser comorbidity index | 1.224 (1.057–1.418) | 0.007 |
| AUC0–24 of ≥677 mg · h/liter | 4.167 (1.639–10.594 | 0.003 |
| Concomitant i.v. contrast dye | 3.798 (1.560–9.248) | 0.003 |
| Elixhauser comorbidity index | 1.283 (1.095–1.502) | 0.002 |
| AUC24–48 of ≥683 mg · h/liter | 3.513 (1.393–8.859) | 0.008 |
| Concomitant i.v. contrast dye | 4.270 (1.723–10.585) | 0.002 |
| Elixhauser comorbidity index | 1.224 (1.059–1.414) | 0.006 |
| Cmin24 of ≥18.8 mg/liter | 3.707 (1.336–10.287) | 0.012 |
| Concomitant i.v. contrast dye | 3.454 (1.422–8.390) | 0.006 |
| Elixhauser comorbidity index | 1.267 (1.080–1.486) | 0.004 |