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Antiviral activity of glecaprevir and HIV-1 PIs alone or in combination in HCV replicon or HIV-1 infectivity assay
| Antiviral assay | Compound(s) | Mean EC50 (nM)a |
|---|---|---|
| HCV genotype 1b Con1 replicon | Glecaprevir | 0.83 |
| Glecaprevir + darunavir | 0.78 | |
| Glecaprevir + lopinavir | 0.84 | |
| HIV-1 pNL4-3 infectivity | Darunavir | 10 |
| Lopinavir | 23 | |
| Darunavir + glecaprevir | 13 | |
| Lopinavir + glecaprevir | 22 |
Values were determined in ≥2 independent experiments.
