Skip to main content
. 2017 Dec 21;62(1):e01454-17. doi: 10.1128/AAC.01454-17

TABLE 1.

MICs of cefiderocol and other antibiotics against Gram-negative and Gram-positive bacteria

Organism Strain MIC (μg/ml)f
CFDC CAZ CFPM MEPM PIPC-TAZ CAZ-AVI CFT-TAZ COL AMK CPFX
Gram-negative bacteria
    Acinetobacter baumannii ATCC 19606 0.063 8 16 1 16 16 2 0.5 16 1
    Acinetobacter calcoaceticus ATCC 23055 0.063 0.125 0.063 ≤0.031 ≤0.031 0.063 ≤0.031 0.25 0.25 ≤0.031
    Acinetobacter haemolyticus ATCC 17906 ≤0.031 2 1 0.25 ≤0.031 4 ≤0.031 1 >32 0.125
    Acinetobacter johnsonii ATCC 17909 0.125 8 2 0.25 ≤0.031 16 ≤0.031 0.25 1 0.25
    Acinetobacter lwoffii ATCC 15309 ≤0.031 1 0.25 0.063 ≤0.031 2 ≤0.031 0.125 0.5 0.25
    Aeromonas hydrophila IFO3820 0.125 0.5 0.063 2 4 0.25 1 >32 2 ≤0.031
    Bordetella parapertussis NCTC 5952 1 1 1 ≤0.031 ≤0.031 0.5 1 ≤0.031 2 ≤0.031
    Burkholderia cepacia ATCC 25416 ≤0.031 4 32 4 32 2 2 >32 >32 1
    Burkholderia multivorans SR01869 2 2 32 4 >32 2 4 >32 >32 4
    Campylobacter jejuni ATCC 33560 >4 >16 2 0.015 64 4 NT NT NT 0.25
    Campylobacter jejuni 794009 >4 >16 2 0.015 64 4 NT NT NT >4
    Citrobacter freundii ATCC 8090 0.063 1 ≤0.031 ≤0.031 1 0.125 0.25 0.5 2 ≤0.031
    Elizabethkingia meningoseptica NCTC 10016 1 >32 >32 16 >32 >32 >32 >32 32 8
    Enterobacter aerogenes ATCC 13048 ≤0.031 1 0.063 0.063 4 0.5 0.5 0.25 2 ≤0.031
    Enterobacter cloacae ATCC 13047 0.5 8 0.125 0.063 16 0.5 8 >32 2 ≤0.031
    Enterobacter cloacaea NCTC 13464 0.125 2 8 0.063 2 0.25 0.5 0.25 2 ≤0.031
    Escherichia coli ATCC 25922 0.125 0.5 0.125 ≤0.031 2 0.5 0.25 0.5 1 ≤0.031
    Escherichia coli ATCC 35218 ≤0.031 0.25 0.125 ≤0.031 1 0.125 0.25 0.5 2 ≤0.031
    Escherichia colia NCTC 13462 2 8 >32 ≤0.031 2 1 2 0.25 4 0.25
    Haemophilus influenzae ATCC 10211 0.25 0.063 ≤0.031 0.063 ≤0.031 ≤0.031 0.125 0.25 8 ≤0.031
    Haemophilus influenzae ATCC 49247 2 0.5 1 0.125 0.125 0.125 1 0.25 8 ≤0.031
    Haemophilus parainfluenzae ATCC 7901 0.25 ≤0.031 ≤0.031 ≤0.031 ≤0.031 ≤0.031 ≤0.031 0.25 1 ≤0.031
    Klebsiella oxytoca ATCC 13182 0.063 0.25 0.125 0.063 4 0.5 0.5 0.25 2 0.063
    Klebsiella pneumoniae ATCC 43816 ≤0.031 0.125 0.063 0.063 2 0.25 0.25 0.25 1 0.063
    Moraxella catarrhalis ATCC 25238 ≤0.031 0.063 0.125 ≤0.031 ≤0.031 0.063 ≤0.031 1 0.5 ≤0.031
    Morganella morgannii ATCC 25830 ≤0.031 0.125 0.063 0.125 ≤0.031 0.063 0.125 >32 1 ≤0.031
    Neisseria gonorrhoeae ATCC 49226 0.5 0.12 0.12 0.03 ≤0.25 0.12 NT NT NT 0.004
    Neisseria gonorrhoeaeb 867807 0.25 0.12 0.06 0.015 ≤0.25 0.12 NT NT NT 0.008
    Neisseria gonorrhoeaec 868339 >4 >16 >8 0.06 1 >16 NT NT NT >4
    Neisseria meningitidis ATCC 13077 0.125 0.063 ≤0.031 ≤0.031 ≤0.031 ≤0.031 ≤0.031 >32 8 ≤0.031
    Proteus mirabilis ATCC 29906 ≤0.031 0.25 0.125 0.125 0.5 0.125 0.5 >32 4 ≤0.031
    Proteus vulgaris ATCC 13315 ≤0.031 0.125 0.063 0.125 ≤0.031 0.063 0.25 32 0.5 ≤0.031
    Providencia alcalifaciens ATCC 9886 ≤0.031 0.25 0.063 0.063 2 0.25 0.125 >32 4 ≤0.031
    Providencia rettgeri ATCC 29944 ≤0.031 0.25 1 0.063 4 0.25 >32 >32 0.5 ≤0.031
    Providencia stuartii ATCC 29914 ≤0.031 0.25 0.063 0.125 1 0.5 0.25 >32 0.5 ≤0.031
    Pseudomonas aeruginosa ATCC 27853 0.5 2 2 0.25 2 2 0.5 0.5 4 0.25
    Pseudomonas aeruginosad NCTC 13437 0.5 >32 >32 >32 >32 >32 >32 1 32 32
    Pseudomonas putida ATCC 12633 0.125 2 2 1 8 2 0.5 0.5 0.5 0.063
    Pseudomonas stutzerii ATCC 11607 0.125 0.5 0.125 0.125 2 0.5 0.125 0.125 0.5 ≤0.031
    Salmonella enterica serovar Choleraesuis ATCC 51741 0.015 0.5 0.06 0.03 4 0.5 NT NT NT 0.03
    Salmonella enterica serovar Enteritidis G-14 0.25 1 0.063 ≤0.031 2 0.5 1 1 16 ≤0.031
    Salmonella enterica serovar Paratyphi 598989 0.06 0.5 0.06 0.03 4 0.25 NT NT NT >4
    Salmonella enterica serovar Typhi 673937 0.015 0.5 0.12 0.03 2 0.25 NT NT NT >4
    Salmonella enterica serovar Typhimurium ATCC 13311 ≤0.031 0.5 0.063 ≤0.031 4 0.5 0.5 0.5 2 ≤0.031
    Serratia marcescens ATCC 13880 ≤0.031 0.5 0.25 0.063 2 1 0.5 >32 1 0.063
    Shigella flexnerie 705927 0.5 0.06 0.25 0.03 2 0.06 NT NT NT 0.015
    Stenotrophomonas maltophilia ATCC 13637 0.125 32 >32 >32 >32 32 32 1 4 0.25
    Vibrio fluvialis NCTC 11327 0.25 0.25 0.25 0.25 4 0.5 4 0.25 2 ≤0.031
    Vibrio vulnificus ATCC 27562 1 0.5 1 ≤0.031 0.063 ≤0.031 2 4 2 ≤0.031
    Yersinia enterocolitica ATCC 9610 ≤0.031 0.125 0.063 0.063 1 0.125 0.25 0.25 2 0.063
    Yersinia pseudotuberculosis ATCC 29833 0.5 0.25 0.063 ≤0.031 0.5 0.25 0.25 >32 2 ≤0.031
Gram-positive bacteria
    Bacillus subtilis ATCC 6633 32 4 1 0.063 0.25 4 2 8 0.25 ≤0.031
    Enterococcus faecalis ATCC 29212 >32 >32 16 2 2 >32 32 >32 >32 1
    Lactobacillus casei ATCC 393 >32 4 32 1 0.5 4 2 >32 2 1
    Micrococcus luteus ATCC 9341 4 0.5 ≤0.031 0.063 ≤0.031 0.5 0.5 >32 1 2
    Staphylococcus aureus ATCC 29213 32 8 8 0.125 1 8 32 >32 2 0.5
    Streptococcus pneumoniae ATCC 49619 2 0.5 ≤0.031 0.063 0.5 0.5 0.25 >32 32 0.5
    Streptococcus pyogenes ATCC 10389 1 0.125 ≤0.031 ≤0.031 0.063 0.125 0.125 >32 16 0.125
a

CTX-M type β-lactamase producer.

b

Resistant to azithromycin.

c

Resistant to ceftriaxone.

d

VIM-10 and VEB-1 β-lactamase producer.

e

Resistant to tetracycline and trimethoprim-sulfamethoxazole.

f

MICs of cefiderocol (CFDC) were determined in iron-depleted cation-adjusted Mueller Hinton broth (ID-CAMHB), and those of other antibiotics were determined in CAMHB except when the following was used (see supplemental method 2): (i) CAMHB supplemented with 2.5 to 5.0% lysed horse blood for B. parapertussis, Streptococcus pneumoniae, Streptococcus pyogenes, Campylobacter jejuni, Neisseria meningitidis, and Lactobacillus casei, (ii) Haemophilus test medium broth for Haemophilus spp., or (iii) GC agar supplemented with 1% defined growth supplement for Neisseria gonorrhoeae, except for meropenem, which was determined on GC agar supplemented with 1% defined growth supplement without cysteine component. NT, not tested; CFDC, cefiderocol; CAZ, ceftazidime; CFPM, cefepime; MEPM, meropenem; PIPC-TAZ, piperacillin-tazobactam; CAZ-AVI, ceftazidime-avibactam; CFT-TAZ, ceftolozane-tazobactam; COL, colistin; AMK, amikacin; CPFX, ciprofloxacin. TAZ and AVI were at a fixed concentration of 4 μg/ml. MICs of PIPC-TAZ, CAZ-AVI, and CFT-TAZ are represented as the concentrations of PIPC, CAZ, and CFT, respectively.