TABLE 4.
MICs of cefiderocol against Gram-negative bacteria harboring β-lactamases
| Organism | Strain | β-Lactamase(s) | MIC (μg/ml)a |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CFDC | CAZ | CFPM | MEPM | PIPC-TAZ | CAZ-AVI | CFT-TAZ | COL | AMK | CPFX | |||
| E. coli | SR34250 | CTX-M-14, TEM-1 | 0.125 | 2 | 4 | ≤0.031 | 2 | 0.25 | 0.5 | 0.25 | 2 | 32 |
| E. coli | SR34201 | CTX-M-15, TEM-1 | 2 | >32 | >32 | 0.063 | 2 | 0.25 | 0.5 | 0.5 | 2 | 32 |
| E. coli | SR34241 | CTX-M-27 | 1 | 8 | 8 | ≤0.031 | 2 | 0.25 | 0.5 | 0.25 | 2 | >32 |
| E. coli | ATCC BAA-196 | TEM-10 | 1 | >32 | 4 | ≤0.031 | 8 | 2 | 2 | 0.25 | 8 | 0.25 |
| E. coli | ATCC BAA-198 | TEM-26 | 0.5 | >32 | 4 | ≤0.031 | 4 | 1 | 1 | 0.25 | 2 | 0.25 |
| K. pneumoniae | ATCC 51983 | SHV-5 | 0.5 | >32 | 2 | 0.063 | 2 | 0.25 | 1 | 0.5 | 2 | ≤0.031 |
| K. pneumoniae | ATCC 700603 | SHV-18 | 1 | 32 | 0.5 | 0.063 | 16 | 0.5 | 1 | 0.25 | 1 | 0.5 |
| K. pneumoniae | NUBL-KG502 | GES-4 | 0.25 | >32 | 16 | 16 | 32 | 16 | >32 | 0.25 | 32 | 0.063 |
| P. aeruginosa | SR24837 | PER-1 | 4 | >32 | >32 | 8 | >32 | >32 | >32 | 0.5 | 8 | 1 |
| K. pneumoniae | VA-360 | KPC-2, TEM-1, SHV-11, SHV-12 | 8 | >32 | >32 | >32 | >32 | 2 | >32 | 0.25 | 16 | >32 |
| K. pneumoniae | VA-375 | KPC-3, TEM-1, SHV-11, SHV-14 | 2 | >32 | 32 | 32 | >32 | 2 | >32 | 0.25 | 8 | >32 |
| E. coli | NUBL-24 | IMP-1 | 1 | >32 | >32 | 8 | 16 | >32 | >32 | 0.25 | 2 | >32 |
| P. aeruginosa | SR27060 | IMP-1 | 0.25 | >32 | >32 | >32 | >32 | >32 | >32 | 1 | 16 | 32 |
| A. baumannii | SBRKM-181 | IMP-1 | 0.125 | >32 | >32 | 32 | 32 | >32 | >32 | 0.5 | 16 | 0.5 |
| K. pneumoniae | SR08933 | IMP-6 | 0.125 | >32 | >32 | 32 | 4 | >32 | >32 | 0.5 | 1 | 32 |
| E. coli | IR5 | NDM-1, CTX-M-15, OXA-9 | 2 | >32 | >32 | >32 | >32 | >32 | >32 | 0.25 | >32 | >32 |
| K. pneumoniae | I1 | NDM-1, SHV-12 | 2 | >32 | >32 | 32 | >32 | >32 | >32 | 8 | >32 | >32 |
| K. pneumoniae | KI2 | NDM-1, OXA-1, CTX-M-15, CMY-6, TEM-1, SHV-28, OXA-9 | 4 | >32 | >32 | >32 | >32 | >32 | >32 | 0.25 | >32 | >32 |
| P. aeruginosa | AK54 | VIM-2 | 0.125 | 32 | 16 | >32 | >32 | 32 | >32 | 1 | >32 | 16 |
| P. aeruginosa | DM3355 | VIM-6 | 2 | >32 | >32 | >32 | >32 | >32 | >32 | 1 | >32 | >32 |
| P. aeruginosa | P0510 | VIM-1 | 0.5 | 32 | 32 | >32 | >32 | 32 | >32 | 1 | >32 | 16 |
| E. coli | SR09616 | CMY-2 | 0.125 | >32 | 1 | 0.063 | 32 | 0.25 | 4 | 0.5 | 2 | 0.25 |
| K. pneumoniae | NUBL-HKY327 | CMY-19 | 1 | >32 | >32 | 0.063 | >32 | >32 | >32 | 0.25 | 16 | ≤0.031 |
| K. pneumoniae | SR09603 | CMY-8 | 0.063 | 8 | 0.125 | 0.25 | 8 | 0.25 | 0.5 | 0.25 | 8 | ≤0.031 |
| K. pneumoniae | SR09635 | DHA | 0.125 | >32 | 0.125 | 0.125 | >32 | 0.25 | 1 | 0.25 | 0.5 | 0.5 |
| S. marcescens | SR36500 | AmpC | 0.125 | 8 | 1 | 0.25 | 16 | 2 | 8 | >32 | 16 | 4 |
| P. aeruginosa | TESS | AmpC | 0.25 | 32 | 16 | 16 | >32 | 4 | 2 | 0.5 | >32 | 32 |
| A. baumannii | 585 | OXA-23 | 0.063 | >32 | 32 | >32 | >32 | 8 | 16 | 0.25 | >32 | >32 |
| A. baumannii | CHAR | OXA-58 | 1 | >32 | 32 | 16 | >32 | >32 | >32 | 16 | >32 | >32 |
| A. baumannii | NCTC 13303 | OXA-26, OXA-51-like | 0.5 | >32 | >32 | >32 | >32 | >32 | >32 | 0.5 | >32 | >32 |
| A. baumannii | NCTC 13422 | OXA-51-like | 0.5 | >32 | >32 | 8 | >32 | >32 | >32 | 0.5 | >32 | >32 |
| A. baumannii | NCTC 13424 | OXA-23, OXA-51-like | ≤0.031 | >32 | 32 | 32 | >32 | 32 | 32 | 0.5 | >32 | >32 |
| K. pneumoniae | PLE | OXA-48 | ≤0.031 | 1 | 2 | 2 | >32 | 0.25 | 1 | 0.25 | 2 | >32 |
a
MICs of cefiderocol were determined in iron-depleted cation-adjusted Mueller Hinton broth (ID-CAMHB), and those of other antibiotics were determined in CAMHB. CFDC, cefiderocol; CAZ, ceftazidime; CFPM, cefepime; MEPM, meropenem; PIPC-TAZ, piperacillin-tazobactam; CAZ-AVI, ceftazidime-avibactam; CFT-TAZ, ceftolozane-tazobactam; COL, colistin; AMK, amikacin; CPFX, ciprofloxacin. TAZ and AVI were at a fixed concentration of 4 μg/ml. MICs of PIPC-TAZ, CAZ-AVI, and CFT-TAZ are represented as the concentrations of PIPC, CAZ and CFT, respectively.