TABLE 6.
Effects of transposon insertion into genes for iron transporters, efflux pump, and porin on the activities of cefiderocol against P. aeruginosa PAO1
| Strain | Descriptiona | MIC (μg/ml)b |
||||
|---|---|---|---|---|---|---|
| Cefiderocol | Ceftazidime | Imipenem | Ciprofloxacin | Aztreonam | ||
| PAO1 | 0.125 | 2 | 1 | 0.125 | 4 | |
| PW1781 | mexB (Tn) | 0.063 | 1 | 1 | 0.063 | 0.25 |
| PW1783 | oprM (Tn) | 0.063 | 1 | 1 | ≤0.031 | 0.25 |
| PW1776 | mexR (Tn) | 0.25 | 8 | 1 | 0.5 | 16 |
| PW7066 | nalD (Tn) | 0.25 | 8 | 1 | 0.5 | 16 |
| PW2742 | oprD (Tn) | 0.25 | 1 | 8 | 0.25 | 4 |
| PW1861 | fiuA (Tn) | 0.063 | 2 | — | — | — |
| PW2689 | pirA (Tn) | 0.063 | 2 | — | — | — |
| PW3399 | pfuA (Tn) | 0.063 | 2 | — | — | — |
| PW4366 | feuA (cirA) (Tn) | 0.063 | 2 | — | — | — |
| PW5036 | fpvA (Tn) | 0.063 | 2 | — | — | — |
| PW5144 | foxA (optS) (Tn) | 0.125 | 2 | — | — | — |
| PW5503 | pfeA (Tn) | 0.063 | 1 | — | — | — |
| PW7590 | fecA (Tn) | 0.063 | 1 | — | — | — |
| PW8065 | fpvB (Tn) | 0.063 | 2 | — | — | — |
| PW8161 | fptA (Tn) | 0.125 | 2 | — | — | — |
| PW8599 | piuA (Tn) | 2 | 2 | — | — | — |
| SR-L00016 | piuA (Tn) and pirA (deletion) | 2 | 2 | — | — | — |
| SR-L00197 | piuA (Tn)/pMMB67HE-Gm | 2 | 1 | — | — | — |
| SR-L00252 | piuA (Tn)/pMMB67HE-Gm-piuA | 0.063 | 1 | — | — | — |
a
Tn, transposon insertion.
b
—, not tested. MICs of cefiderocol were determined in ID-CAMHB, and those of references were determined in CAMHB.