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. Author manuscript; available in PMC: 2017 Dec 22.
Published in final edited form as: Biochemistry. 2017 Aug 29;56(36):4786–4798. doi: 10.1021/acs.biochem.7b00619

Figure 1. Structures of ecDHFR complexed with phenformin and buformin.

Figure 1

A) Ribbon diagram showing the active site of the ecDHFR-phenformin complex. Major sidechain interactions with PFM are indicated. B) Ribbon diagram showing a similar complex with buformin. C) Ribbon diagram illustrating the analogous interactions with bound methotrexate (pdb: 1RA3). Hydrogen bonds are indicated with black dashed lines.