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. Author manuscript; available in PMC: 2017 Dec 22.
Published in final edited form as: Biochemistry. 2017 Aug 29;56(36):4786–4798. doi: 10.1021/acs.biochem.7b00619

Figure 3. Schematic illustrating the pteridine- and pABG-binding subsites of the DHFR folate binding site.

Figure 3

The panels illustrate how the subsites are occupied by (A) folate; (B) 2,4-diaminopyrimidine (DAP) and pABG; (C) metformin (MFM) and pABG; (D) MFM and a 4-methyl-substituted hippurate; (E) MFM and the NSAID Fenbufen. Double-headed arrows indicate ILOE interactions.