UFH reduces APC depletion and the shedding of EPCR and TM following LPS induction. Serum levels of (A) APC, (B) sEPCR and (C) sTM were measured by ELISA at 3, 6 and 12 h post LPS administration (n=4/group). *P<0.05 vs. the control group; #P<0.05 vs. the LPS group. UFH, unfractionated heparin; APC, activated protein c; sEPCR, soluble endothelial protein C receptor; sTM, soluble thrombomodulin; LPS, lipopolysaccharide.