Table I.
The comparison of histopathological, PGE-2 activity, and ultrastructural changes in glandular stomach of omeprazole-treated and untreated rats at 4, 7, and 14 days post gastritis induction.
| 4 Day PI | 7 Day PI | 14 Day PI | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Pathology/parameter | Omeprazole (n=5 rats) | Non-treatment (n=5 rats) | P-value | Omeprazole (n=5 rats) | Non-treatment (n=5 rats) | P-value | Omeprazole (n=5 rats) | Non-treatment (n=5 rats) | P-value |
| Mucosa | |||||||||
| Glandular atrophy/dilatation | 52.5±35.4 | 97.5±35.4 | 0.404 | 0.0±0.0 | 30.0±30.0 | 0.374 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Necrosis | 45.5±35.7 | 202.5±70.7 | 0.094 | 0.0±0.0 | 30.0±30.0 | 0.374 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Tissue debris | 22.5±14.3 | 150.0±71.4 | 0.131 | 0.0±0.0 | 0.0±0.0 | 1.000 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Inflammation | 15.0±15.0 | 262.5±22.5 | 0.000 | 0.0±0.0 | 50.0±50.0 | 0.374 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Hemorrhage | 30.0±17.3 | 210.7±71.4 | 0.049 | 0.0±0.0 | 0.0±0.0 | 1.000 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Congestion | 77.5±31.1 | 37.5±10.3 | 0.269 | 5.0±2.8 | 30.0±0.0 | 0.001 | 5.0±2.8 | 3.3±1.6 | 1.000 |
| Submucosa | |||||||||
| Edema | 215.0±31.22 | 187.5±71.8 | 0.737 | 0.0±0.0 | 30.0±30.0 | 0.394 | 0.0±0.0 | 0.0±0.0 | 0.589 |
| Inflammation | 250.0±50.0 | 225.0±75.0 | 0.791 | 0.0±0.0 | 163.3±74.4 | 0.093 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Hemorrhage | 97.5±59.2 | 127.5±43.0 | 0.696 | 0.0±0.0 | 0.0±0.0 | 1.000 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Congestion | 22.5±16.0 | 22.5±7.5 | 1.000 | 3.3±1.6 | 40.0±10.0 | 0.022 | 1.6±1.6 | 1.6±1.6 | 1.000 |
| Fatty degeneration | 82.5±51.0 | 67.5±25.6 | 0.802 | 0.0±0.0 | 16.6±8.8 | 0.132 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Muscularis | |||||||||
| Vacuolated degeneration | 90.0±37.6 | 87.5±55.5 | 0.972 | 0.0±0.0 | 90.0±56.8 | 0.189 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Inflammation | 0.0±0.0 | 22.5±13.1 | 0.138 | 0.0±0.0 | 0.0±0.0 | 1.000 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Hemorrhage | 0.0±0.0 | 22.5±14.3 | 0.168 | 0.0±0.0 | 0.0±0.0 | 1.000 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Congestion | 0.0±0.0 | 7.5±2.5 | 0.024 | 0.0±0.0 | 6.6±1.6 | 0.016 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Grandular PGE-2 (pg/ml) | 2,277.1±291.7 | 1,643.1±89.89 | 0.047 | 3,580.4±714.7 | 1,263.0±20.44 | 0.017 | 1,408.7±13.41 | 986.5±19.21 | 0.000 |
| Gross hemorrhagic area | 14.0±7.2 | 28.2±10.2 | 0.040 | 0.1±0.1 | 1.2±0.5 | 0.985 | 0.0±0.0 | 0.0±0.0 | 1.000 |
| Defected RER in chief cells | 5.2±0.6 | 174.0±8.7 | 0.000 | 5.6±0.8 | 250.0±15.1 | 0.000 | 6.8±0.8 | 6.4±1.0 | 0.899 |
| Defected RER in parietal cells | 5.7±0.8 | 4.7±1.0 | 0.483 | 6.2.0±1.1 | 5.5±0.6 | 0.580 | 6.2±1.2 | 6.5±1.9 | 0.890 |
| Swelling Mito in chief cells | 24.0±6.1 | 26.0±7.0 | 0.796 | 87.3±2.8 | 84.6±9.2 | 0.654 | 15.0±1.1 | 11.0±1.1 | 0.07 |
| Swelling Mito in parietal cells | 36.3±2.9 | 24.0±6.4 | 0.156 | 47.3±2.7 | 28.3±21.6 | 0.840 | 44.0±4.7 | 32.6±6.9 | 0.248 |
Data are presented as the mean ± SEM. RER, rough endoplasmic reticulum; mito, mitochondria.