Table 1.

Overall BC risk estimates for truncating mutations in each gene. Variant category tallies (online supplementary table S4) and carrier counts (online supplementary table S5) are available in the supplementary materials

	Cases			Controls			OR (95% CI)	P-Value
	Carriers	Non-Carriers	Carriers Frequency	Carriers	Non-Carriers	Carrier Frequency
ATM	85	13,002	0.00649	11	5,477	0.00200	3.26 (1.82–6.46)	2.1×10-5
CHEK2	213	12,874	0.01628	29	5,459	0.00528	3.11 (2.15–4.69)	5.6×10-11
PALB2	89	12,998	0.00685	8	5,480	0.00146	4.69 (2.27–9.68)	6.9×10-6
XRCC2	9	13,078	0.00069	4	5,484	0.00073	0.94 (0.26–4.19)	0.92