Table 2b.
Prevalence of anterior hypopituitarism following TBI (<12 months)
| Study | n | GCS | Time from injury | Anterior hypopituitarism (axis affected) | |||||
| Total (%) | GH (%) | FSH/LH (%) | ACTH (%) | TSH (%) | Multiple (%) | ||||
| Abadi et al 67 | 75 | 9–13 | 3 months | 48 | 24 | 16 | 13 | 5.3 | 13 |
| 6 months | – | 9.3 | 10.7 | 4 | 2.7 | – | |||
| Schneider et al 68* | 825 | – | <5 months | 17–39 | 22 | – | – | – | – |
| Krahulik et al 66 | 186 | 3–14 | 3 months | 22.9 | – | – | – | – | – |
| 6 months | 18.2 | – | – | – | – | – | |||
| Klose et al 20 | 46 | 3–15 | 3 months | 13 | – | – | – | – | 6.5 |
| Schneider et al 69 | 78 | 3–15 | 3 months | 56 | 9 | 32 | 19 | 8 | – |
| Agha et al 56 | 48 | 8–13 | 6 months | – | 12.5 | 22.9 | 18.8 | 2.1 | – |
| Aimaretti et al 24 | 100 | 3–15 | 3 months | 35 | 37 | 17 | 8 | 5 | – |
*Patients were categorised into acute (<5 months) or chronic (>5 months) groups in this study.
ACTH, adrenocorticotropic hormone; FSH, follicle-stimulating hormone; GCS, Glasgow Coma Scale; GH, growth hormone; LH, luteinising hormone; TBI, traumatic brain injury; TSH, thyroid-stimulating hormone.