Table 6.
Major interventions in relation to Genetic Severity Score
| Genetic severity | 1 Tissue Mosaic |
2A Mild |
2B Moderate |
3 Severe |
Statistics | ||
| N (%) | Proportion of patients within each genetic severity category who had interventions | VS surgery | 21 (33.3%) | 11 (44.0%) | 16 (45.7%) | 9 (47.4%) | χ2(1)=1.9, p=0.17 |
| Non-VS intracranial surgery | 15 (23.8%) | 5 (20.0%) | 13 (37.1%) | 7 (36.8%) | χ2(1)=2.4, p=0.12 | ||
| Spinal surgery* | 6 (9.5%) | 7 (28.0%) | 10 (28.6%) | 9 (47.4%) | χ2(1)=12.8, p<0.001 | ||
| Shunt surgery | 3 (4.8%) | 3 (12.0%) | 4 (3.2%) | 3 (15.8%) | χ2(1)=2.6, p<0.001 | ||
| Radiotherapy | 28 (44.4%) | 10 (40.0%) | 11 (31.4%) | 8 (42.1%) | χ2(1)=0.6, p=0.44 | ||
| Bevacizumab* | 0 (0.0%) | 5 (20.0%) | 9 (25.7%) | 5 (26.3%) | χ2(1)=15.4, p<0.001 | ||
| Total number of major interventions per person, grouped | 0 | 15 (23.8%) | 6 (24.0%) | 7 (20.0%) | 5 (26.3%) | χ2(1)=7.1, p=0.008 | |
| 1 | 23 (36.5%) | 4 (16.0%) | 8 (22.9%) | 2 (10.5%) | |||
| 2 | 13 (20.6%) | 3 (12.0%) | 7 (20.0%) | 2 (10.5%) | |||
| 3 | 8 (12.7%) | 2 (8.0%) | 3 (8.6%) | 2 (10.5%) | |||
| 4 or more | 4 (6.3%) | 10 (40.0%) | 10 (28.6%) | 8 (42.1%) | |||
| Mean (SD) | Total number of major interventions* | 1.41 (1.17) | 2.84 (2.76) | 2.43 (2.21) | 3.37 (3.44) | rs(140)=0.23, p=0.007 | |
| Number of total surgeries* | 0.87 (0.98) | 2.12 (2.46) | 1.74 (1.82) | 2.53 (2.95) | rs(140)=0.24, p=0.005 | ||
| Age at first radiotherapy session* | 51.54 (14.82) | 34.2 (14.06) | 29.64 (12.17) | 24.13 (10.56) | rs(55)=−0.66, p<0.001 | ||
| Age started bevacizumab* | 34.8 (7.4) | 30.56 (11.59) | 19.8 (4.97) | rs(17)=−0.60, p=0.007 | |||
| Age at first surgery* | 44.33 (12.71) | 27 (10.15) | 27.28 (9.54) | 18.67 (11.82) | rs(87)=−0.63, p<0.001 | ||
| Age at first major intervention* | 45.4 (12.41) | 26.58 (9.37) | 27.71 (11.06) | 17.79 (9.74) | rs(107)=−0.67, p<0.001 | ||
| Ratio of total number of major interventions to current age* | 0.03 (0.02) | 0.07 (0.07) | 0.07 (0.07) | 0.13 (0.14) | rs(140)=−0.38, p<0.001 | ||
Asterisk indicates statistical significance (p<0.05) in trends (χ2) and correlations (rs) of measures with genetic severity.
VS, vestibular schwannoma.