Figure 4.

Effect of resveratrol on the expression of NLRP3 inflammasome in mice infected with S. aureus. Mice were treated with resveratrol for 24 h prior to S. aureus infection. The (A-C) RNA and (D) protein expression of NLRP3, ASC and caspase-1 were measured by reverse-transcription quantitative polymerase chain reaction and western blot. (E) Quantified western blotting results. Values are expressed as the mean ± standard deviation. **P<0.01; ***P<0.001 vs. mice infected with S. aureus 8325-4 after the treatment of PBS. NLRP3, nucleotide-binding domain and leucine-rich repeat containing gene family pyrin domain containing 3 protein; ASC, apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain; S. aureus, Staphylococcus aureus.