Fig. 7.

Effect of TG2 knockdown on the adhesion/migration and cytoskeleton rearrangement in IL-4-activated THP-1 monocytes. SCR or TG2-KD monocytes were treated with IL-4 (50 ng/ml) for 24 h and then examined for a their ability to adhere onto a FN layer for 1 h, b mRNA expression of β1 integrin, c activation of the small GTPase protein RhoA, and d mRNA expression of MMP-2. Data presented are the mean values + SEM (standard error of the mean) of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001. SCR scramble control, TG2-KD TG2 knockdown