Fig. 6.

Increased antiviral gene expression in response to HIV-1 infection in BICD2 knockout cells. Control and BICD2 knockout THP1 differentiated macrophages infected with R7ΔEnvGFP pseudotyped with either JRFL, HXB2, or VSV glycoproteins. Cells were harvested 24 h postinfection and expression of IFIT1, IFI27, IP10, and STAT1 was measured using qRT-PCR with gene specific primers. Fold increase in mRNA expression compared with uninfected control. Error bar represents SD of samples run in triplicate. The data shown here are representative of three or more experiments.